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For the EAVI2020, Dr. Arts and his team will be engaged and integrated into multiple components by providing a reagents (HIV-1 isolates of different subtypes, envelope expression constructs, etc) (WP1&4) to the team, by providing new intellectual property (incorporation of the N425K mutations to enhance antigen presentation of the Envelope- based vaccine constructs) (WP1), and by performing specific studies related to possible immune escape in patients receiving therapeutic vaccines (WP3).http://www.uwo.ca/