Publications

The EAVI2020 project has contributed to many scientific publications. Below is a list of these publications and their journal links. All are freely accessible and acknowledge EAVI2020’s funding body, the European Commission:

• Moron-Lopez, S., Urrea, V., Dalmau, J., Lopez, M., Puertas, M.C., Ouchi, D., Gómez, A., Passaes, C., Mothe, B., Brander, C. and Saez-Cirion, A., (2021). The Genome-wide Methylation Profile of CD4+ T Cells From Individuals With Human Immunodeficiency Virus (HIV) Identifies Distinct Patterns Associated With Disease Progression. Clinical Infectious Diseases, 72(9), pp.e256-e264. DOI: 10.1093/cid/ciaa1047

• Bernat, N.V., Corcoran, M., Nowak, I., Kaduk, M., Dopico, X.C., Narang, S., Maisonasse, P., Dereuddre-Bosquet, N., Murrell, B. and Hedestam, G.B.K., (2021). Rhesus and cynomolgus macaque immunoglobulin heavy-chain genotyping yields comprehensive databases of germline VDJ alleles. Immunity, 54(2), pp.355-366. DOI: 10.1016/j.immuni.2020.12.018

• Derking, R., Allen, J.D., Cottrell, C.A., Sliepen, K., Seabright, G.E., Lee, W.H., Aldon, Y., Rantalainen, K., Antanasijevic, A., Copps, J. and Yasmeen, A., (2021). Enhancing glycan occupancy of soluble HIV-1 envelope trimers to mimic the native viral spike. Cell Reports, 35(1), p.108933. DOI: 10.1016/j.celrep.2021.108933

• Brouwer, P.J., Antanasijevic, A., de Gast, M., Allen, J.D., Bijl, T.P., Yasmeen, A., Ravichandran, R., Burger, J.A., Ozorowski, G., Torres, J.L. and LaBranche, C., (2021). Immunofocusing and enhancing autologous Tier-2 HIV-1 neutralization by displaying Env trimers on two-component protein nanoparticles. NPJ vaccines, 6(1), pp.1-14. DOI: 10.1038/s41541-021-00285-9

• Sanders, R.W. and Moore, J.P., (2021). Virus vaccines: proteins prefer prolines. Cell Host & Microbe, 29(3), pp.327-333. DOI: 10.1016/j.chom.2021.02.002

• Caillat, C., Guilligay, D., Torralba, J., Friedrich, N., Nieva, J.L., Trkola, A., Chipot, C.J., Dehez, F.L. and Weissenhorn, W., (2021). Structure of HIV-1 gp41 with its membrane anchors targeted by neutralizing antibodies. Elife, 10, p.e65005. DOI: 10.7554/elife.65005

• Dispinseri, S., Cavarelli, M., Tolazzi, M., Plebani, A.M., Jansson, M. and Scarlatti, G., (2021). Continuous hiv-1 escape from autologous neutralization and development of cross-reactive antibody responses characterizes slow disease progression of children. Vaccines, 9(3), p.260. DOI: 10.3390/vaccines9030260

• Seabright, G.E., Cottrell, C.A., van Gils, M.J., D’addabbo, A., Harvey, D.J., Behrens, A.J., Allen, J.D., Watanabe, Y., Scaringi, N., Polveroni, T.M. and Maker, A., (2020). Networks of HIV-1 envelope glycans maintain antibody epitopes in the face of glycan additions and deletions. Structure, 28(8), pp.897-909. DOI: 10.1101/2020.02.21.95998

• Oriol-Tordera, B., Olvera, A., Duran-Castells, C., Llano, A., Mothe, B., Massanella, M., Dalmau, J., Ganoza, C., Sanchez, J., Calle, M.L. and Clotet, B., (2020). TL1A–DR3 Plasma Levels Are Predictive of HIV-1 Disease Control, and DR3 Costimulation Boosts HIV-1–Specific T Cell Responses. The Journal of Immunology, 205(12), pp.3348-3357. DOI: 10.4049/jimmunol.200093

• Blasi, M., Negri, D., Saunders, K.O., Baker, E.J., Stadtler, H., LaBranche, C., Mildenberg, B., Morton, G., Ciarla, A., Shen, X. and Wang, Y., (2020). Immunogenicity, safety, and efficacy of sequential immunizations with an SIV-based IDLV expressing CH505 Envs. NPJ vaccines, 5(1), pp.1-12. DOI: 10.1038/s41541-020-00252-w

• Tannig, P., Peter, A.S., Lapuente, D., Klessing, S., Schmidt, A., Damm, D., Tenbusch, M., Überla, K. and Temchura, V., (2020). Genetic co-administration of soluble PD-1 ectodomains modifies immune responses against influenza a virus induced by DNA vaccination. Vaccines, 8(4), p.570. DOI: 10.3390/vaccines8040570

• Antanasijevic, A., Ueda, G., Brouwer, P.J., Copps, J., Huang, D., Allen, J.D., Cottrell, C.A., Yasmeen, A., Sewall, L.M., Bontjer, I. and Ketas, T.J., (2020). Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens. PLoS pathogens, 16(8), p.e1008665. DOI: 10.1371/journal.ppat.1008665

• Sekine, T., Perez-Potti, A., Nguyen, S., Gorin, J.B., Wu, V.H., Gostick, E., Llewellyn-Lacey, S., Hammer, Q., Falck-Jones, S., Vangeti, S. and Yu, M., (2020). TOX is expressed by exhausted and polyfunctional human effector memory CD8+ T cells. Science immunology, 5(49). DOI: 10.1126/sciimmunol.aba7918

• Klessing, S., Temchura, V., Tannig, P., Peter, A.S., Christensen, D., Lang, R. and Überla, K., 2020. CD4+ T Cells Induced by Tuberculosis Subunit Vaccine H1 Can Improve the HIV-1 Env Humoral Response by Intrastructural Help. Vaccines, 8(4), p.604. DOI: 10.3390/vaccines8040604

• Olvera, A., Cedeño, S., Llano, A., Mothe, B., Sanchez, J., Arsequell, G., & Brander, C. (2020). Does antigen glycosylation impact the HIV-specific T cell immunity?. Frontiers in immunology, 11. DOI: 10.3389/fimmu.2020.573928

• Díez-Fuertes, F., De La Torre-Tarazona, H. E., Calonge, E., Pernas, M., Bermejo, M., García-Pérez, J., … & Alcami, J. (2020). Association of a single nucleotide polymorphism in the ubxn6 gene with long-term non-progression phenotype in HIV-positive individuals. Clinical Microbiology and Infection, 26(1), 107-114. DOI: 10.1016/j.cmi.2019.05.015

• Cottrell, C. A., van Schooten, J., Bowman, C. A., Yuan, M., Oyen, D., Shin, M., … & van Gils, M. J. (2020). Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates. PLoS pathogens, 16(8), e1008753. DOI: 10.1371/journal.ppat.1008753

• Sanchez, J., Gonçalves, E., Llano, A., Gonzáles, P., Fernández-Maldonado, M., Vogt, A., … & Combadiere, B. (2020). Immune Profiles Identification by Vaccinomics After MVA Immunization in Randomized Clinical Study. Frontiers in Immunology, 11, 2866. DOI: 10.3389/fimmu.2020.586124

• Saubi, N., Kilpeläinen, A., Eto, Y., Chen, C-W., Olvera, À., Hanke, T., Joseph-Munné, J. & Brander, C. (2020). Priming with Recombinant BCG Expressing HTI Enhances the Magnitude and Breadth of the T-Cell Immune Responses Elicited MVA.HTI in BALB/c Mice. Vaccines (Basel), 8-4, pp.678. DOI: 10.3390/vaccines8040678

• Chen, C-W., Saubi, N. & Joseph-Munné, J. (2020). Design Concepts of Virus-Like Particle-Based HIV-1. Vaccines Front Immunol, 11, pp.573157. DOI: 10.3389/fimmu.2020.573157

• Gallinaro, A., Borghi, M., Pirillo, M.F., Cecchetti, S., Bona, R., Canitano, A., Michelini, Z., Di Virgilio, A., Olvera, A., Brander, C., Negri & D., Cara, A. (2020). Development and Preclinical Evaluation of an Integrase Defective Lentiviral Vector Vaccine Expressing the HIVACAT T Cell Immunogen in Mice. Molecular Therapy Methods & Clinical Development. DOI: 10.1016/j.omtm.2020.01.013

• Oriol-Tordera, B., Berdasco, M., Llano, A., Mothe, B., Gálvez, C., Martinez-Picado, J., Carrillo, J., Blanco, J., Duran-Castells, C., Ganoza, C., Sanchez, J., Clotet, B., Calle, M.L., Sanchez-Pla, A., Esteller, M., Brander, C. & Ruiz-Riol, M. (2020). Methylation regulation of Antiviral host factors, Interferon Stimulated Genes (ISGs) and T-cell responses associated with natural HIV control. PLOS Pathogens. DOI: 10.1371/journal.ppat.1008678

• Yi-Yu, L., Belle, I., Blasi, M., Min-Nung, H., Buckley, A.F., Rountree, W., Klotman, M.E., Cara, A. & Negri, D. (2020). Skeletal muscle is an antigen reservoir in integrase-defective lentiviral vector-induced long-term immunity. Molecular Therapy Methods & Clinical Development. DOI: 10.1016/j.omtm.2020.03.008

• Blasi, M., Wescott, E.C., Baker, E.J., Mildenberg, B., LaBranche, C., Rountree, W., Haynes, B.F., Saunders, K.O., Moody, M.A., Negri, D., Santra, S., Cara, A. & Klotman, M.E. (2020). Therapeutic vaccination with IDLV-SIV-Gag results in durable viremia control in chronically SHIV-infected macaques. NPJ Vaccines. DOI: 10.1038/s41541-020-0186-5

• Silva-Arrieta, S., Goulder, P.J.R. & Brander, C. (2020). In silico veritas? Potential limitations for SARS-CoV-2 vaccine development based on T-cell epitope prediction. PLOS Pathogens. DOI: 10.1371/journal.ppat.1008607

• Bailon, L.,  Mothe, B., Berman, C. & Brander, C. (2020). Novel Approaches Towards a Functional Cure of HIV/AIDS. DRUGS. DOI: 10.1007/s40265-020-01322-y

• Mohamed, Y.S., Borthwick, N.J., Moyo, N., Murakoshi, H., Akahoshi, T., Siliquini, F., Hannoun, Crook, A., Hayes, P., Fast, P.E., Mutua, G., Jaoko, W., Silva-Arrieta, S., Llano, A., Brander, C., Takiguchi, M. & Hanke, T. (2020). Specificity of CD8 + T-Cell Responses Following Vaccination With Conserved Regions of HIV-1 in Nairobi, Kenya. Vaccines. DOI: 10.3390/vaccines8020260

• Mothe, B., Rosás-Umbert, M., Coll, P., Manzardo, C., Puertas, M.C., Morón-López, S., Llano, A., Miranda, C., Cedeño, S., López, M., Alarcón-Soto, Y., Melis, G.G., Langohr, K., Barriocanal, A.M., Toro, J., Ruiz, I., Rovira, C., Carrillo, A., Meulbroek, M., Crook, A., Wee, E.G., Miró, J.M., Clotet, B., Valle, M., Martinez-Picado, J., Hanke, T., Brander, C., Moltó, J. & The BCN02 Study Investigators (2020). HIVconsv Vaccines and Romidepsin in Early-Treated HIV-1-Infected Individuals: Safety, Immunogenicity and Effect on the Viral Reservoir (Study BCN02). Immunol. DOI: 10.3389/fimmu.2020.00823

• Rosás-Umbert, M., Ruiz-Riol, M., Fernández, M.A., Marszalek, M., Coll, P., Manzardo, C., Cedeño, S., Miró, J.M., Clotet, B., Hanke, T., Moltó, J., Mothe, B., Brander, C. & The BCN02 Study Group (2020). In vivo Effects of Romidepsin on T-Cell Activation, Apoptosis and Function in the BCN02 HIV-1 Kick&Kill Clinical Trial. Immunol. DOI: 10.3389/fimmu.2020.00418
• Borthwick, N., Silva-Arieta, S., Llano, A., Takiguchi, M., Brander, C. & Hanke, T. (2020). Novel nested peptide epitopes recognized by CD4+ T cells induced by HIV-1 conserved-region vaccines. Vaccines. DOI: 10.3390/vaccines8010028

• Suleiman, E., Mayer, J., Lehner, E., Kohlhauser, B., Katholnig, A., Batzoni, M., Damm, D., Temchura, V., Wagner, A., Überla, K. & Vorauer-Uhl, K. (2020). Conjugation of Native-Like HIV-1 Envelope Trimers onto Liposomes Using EDC/Sulfo-NHS Chemistry: Requirements and Limitations. Pharmaceutics. DOI: 10.3390/pharmaceutics12100979

• Blasi, M., Negri, D., Saunders, O.K., Baker, J.E., Stadtler, H., LaBranche, C., Mildenberg, B., Morton, G., Ciarla, A., Shen, X., Wang, Y., Rountree, W., Balakumaran, B., Santra, S., Haynes, F.B., Moody, M.A., Cara, A. & Klotman, E.M. (2020). Immunogenicity, safety and efficacy of sequential immunizations with an SIV-based IDLV expressing CH505 Envs. npj Vaccines. DOI:10.1101/2020.03.06.980680

• Caillat, C., Guilligay, D., Sulbaran, G. & Weissenhorn, W. (2020). Neutralizing Antibodies Targeting HIV-1 gp41. Vaccines. DOI: 10.3390/v12111210

• Schorcht, A., Van den Kerkhof, T., Cottrell, C., Allen, J., Torres, V., Behrens, A.J., Schermer, E., Burger, J., De Taeye, S., Torrents de la Pena, A., Bontjer, I., Gumbs, S., Ozorowski, G., LaBranche, C., De Val, N., Yasmeen, A., Klasse, P.J., Montefiori, D., Moore, J.P., Schuitemaker, H., Crispin, M., Van Gils, M.J., Ward, A.B. & Sanders, R.W. (2020). Neutralizing Antibody Responses Induced by HIV-1 Envelope Glycoprotein SOSIP Trimers Derived from Elite Neutralizers. Journal of Virology. DOI: 10.1128/JVI.01214-20

• Yuan, M., Cottrell, C.A., Ozorowski, G., Van Gils, M.J., Kumar, S., Wu, N.C., Sarkar, A., Torres, J.L., De Val, N., Copps, J., Moore, J.P., Sanders, R.W., Ward, A.B. & Wilson, I.A. (2020). Conformational Plasticity in the HIV-1 Fusion Peptide Facilitates Recognition by Broadly Neutralizing Antibodies. Cell Host & Microbe. Vol 25(6). DOI: 10.1016/j.chom.2019.04.011.

• Kilpelainen, A. Saubi, N., Guitart, N., Olvera, A., Hanke, T., Brander, C. & Joseph-Munné, J. (2019). Recombinant BCG Expressing HTI Prime and Recombinant ChAdOx1 Boost Is Safe and Elicits HIV-1-Specific T-Cell Responses in BALB/c Mice. Vaccines. MDPI, 7-3. ISSN 2076-393X. DOI: 10.3390/vaccines7030078

• Diez-Fuertes, F., De La Torre-Tarazona, H. E., Calonge, E., Pernas, M., del Mar Alonso-Socas, M., Capa, L., … & Alcamí, J. (2019). Transcriptome sequencing of peripheral blood mononuclear cells from elite controller-long term non progressors. Scientific reports, 9(1), 1-13. DOI: 10.1038/s41598-019-50642-x

• Blakney, A. K., McKay, P. F., Yus, B. I., Aldon, Y., & Shattock, R. J. (2019). Inside out: optimization of lipid nanoparticle formulations for exterior complexation and in vivo delivery of saRNA. Gene therapy, 26(9), 363-372. DOI: 10.1038/s41434-019-0095-2

• Vieillard, V., Combadière, B., Tubiana, R., Launay, O., Pialoux, G., Cotte, L.,  Girard, PM., Simon, A., Dudoit, Y., Reynes, J., Rockstroh, J., Garcia, F., Gatell, J., Devidas, A., Yazdanpanah, Y., Weiss, L., Fätkenheuer, G., Autran, B., Joyeux, D., Gharakhanian, S., Debré, P., Katlama, C. (2019). HIV therapeutic vaccine enhances non-exhausted CD4+ T cells in a randomized phase 2 trial. npj Vaccines Volume 4(25). DOI: 10.1038/s41541-019-0117-5

• del Moral-Sánchez, I., & Sliepen, K. (2019). Strategies for inducing effective neutralizing antibody responses against HIV-1. Expert review of vaccines, 18(11), 1127-1143. DOI: 10.1080/14760584.2019.1690458

• Suleiman, E., Damm, D., Batzoni, M., Temchura, V., Wagner, A., Überla, K., & Vorauer-Uhl, K. (2019). Electrostatically Driven Encapsulation of Hydrophilic, Non-Conformational Peptide Epitopes into Liposomes. Pharmaceutics. DOI: 10.3390/pharmaceutics11110619

• Pinto, D., Fenwick, C., Caillat, C., Silacci, C., Guseva, S., Dehez, F., Chipot, C., Barbieri, S., Minola, A., Jarrossay, D., Tomaras,  G.D., Shen, X., Riva, A., Tarkowski, M., Schwartz, O., Bruel, T., Dufloo, J., Seaman, M.S., Montefiori, D.C., Lanzavecchia, A., Corti, D., Pantaleo, G. & Weissenhorn, W. (2019). Structural Basis for Broad HIV-1 Neutralization by the MPER-Specific Human Broadly Neutralizing Antibody LN01. Cell Host & Microbe. DOI: 10.1016/j.chom.2019.09.016

• Rosás-Umbert, M., Llano, A., Bellido, R., Olvera, A., Ruiz-Riol, M., Rocafort, M., Fernández, M.A., Cobarsi, P., Crespo, M., Dorrell, L., del Romero, J., Alcami, J., Paredes, R., Brander, C., Mothe, B.  (2019). Mechanisms of Abrupt Loss of Virus Control in a Cohort of Previous HIV Controllers. Journal of Virology, volume 93 (4) e01436-18; DOI: 10.1128/JVI.01436-18

• Brouwer, P.J. and Sanders, R.W., 2019. Presentation of HIV-1 envelope glycoprotein trimers on diverse nanoparticle platforms. Current Opinion in HIV and AIDS, 14(4), p.302. DOI: 10.1097/coh.0000000000000549

• Yuan, M., Cottrell, C.A., Ozorowski, G., van Gils, M.J., Kumar, S., Wu, N.C., Sarkar, A., Torres, J.L. Val, N., Copps, J., Moore, J.P., Sanders, R.W., Ward, A.B., Wilson, I.A. (2019). Conformational plasticity in the HIV-1 fusion peptide facilitates recognition by broadly neutralizing antibodies. Cell Host & Microbe. Volume 25(6), June 12, Pages 873-883.e5. DOI: 10.1016/j.chom.2019.04.011

• Brouwer, P.J.M., Antanasijevic, A., Berndsen, Z., Yasmeen, A., Fiala, B., Bijl, T.P.L., Bontjer, I., Bale, J.B., Sheffler, W., Allen, J.D., Schorcht, A., Burger, J.A., Camacho, M., Ellis, D., Cottrell, C.A., Behrens, AJ., Catalano, M., del Moral-Sánchez, I., Ketas, T.J., LaBranche, C., van Gils, M.J., Sliepen, K., Stewart, L.J., Crispin, M., Montefiori, D.C., Baker, D., Moore, J.P., Klasse, P.J., Ward, A.B., King, N.P., Sanders, R.W. (2019). Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle. Nature Communications. Volume 10 (4272). September 19. DOI: 10.1038/s41467-019-12080-1

• Torrents de la Peña, A., Rantalainen, K., Cottrell, C.A., Allen, J.D., van Gils, M.J., Torres, J.L., Crispin, M., Sanders, R.W., Ward, A.B. (2019). Similarities and differences between native HIV-1 envelope glycoprotein trimers and stabilized soluble trimer mimetics. PLoS Pathogens. Volume 15(7). DOI: 10.1371/journal.ppat.1007920

• Watanabe, Y., Bowden, T.A., Wilson, I.A., Crispin, M. (2019). Exploitation of glycosylation in enveloped virus pathobiology. Biochim Biophys Acta Gen Subj. Oct. Volume 1863(10). Pp 1480-1497. DOI: 10.1016/j.bbagen.2019.05.012.

• Broset, E., Saubi, N., Guitart, N., Aguilo, N., Uranga, S., Kilpeläinen, A., Eto, Y., Hanke, T., Gonzalo-Asensio, J., Martín, C., and Joseph-Munné, J. (2019). MTBVAC-Based TB-HIV Vaccine Is Safe, Elicits HIV-T Cell Responses, and Protects against Mycobacterium tuberculosis in Mice. Molecular Therapy Methods & Clinical Development. DOI: 10.1016/j.omtm.2019.01.014
• Seabright, G.E., Doores, K.J., Burton, D.R. and Crispin, M. (2019). Protein and Glycan Mimicry in HIV Vaccine Design. Journal of Molecular Biology. DOI: 10.1016/j.jmb.2019.04.016

• Vázquez Bernat, N., Corcoran, M., Hardt, U., Kaduk, M., Phad, G.E., Martin, M., and Karlsson, H.G.B. (2019). High-Quality Library Preparation for NGS-Based Immunoglobulin Germline Gene Inference and Repertoire Expression Analysis. Frontiers in Immunology. Vol 10. DOI: 10.3389/fimmu.2019.00660

• Heß, R., Storcksdieck Genannt Bonsmann, M., Lapuente, D., Maaske, A., Kirschning, C., Ruland, J., Lepenies, B., Hannaman, D., Tenbusch, M. and Überla, K. (2019). Glycosylation of HIV Env Impacts IgG Subtype Responses to Vaccination. Viruses. 11(2). DOI: 10.3390/v11020153

• Sliepen, K., Han, B.W., Bontjer, I., Mooij, P., Garces, F., Behrens, A., Rantalainen, K., Kumar, S., Sarkar, A., Brouwer, P.J.M., Hua, Y., Tolazzi, M., Schermer, E., Torres, J.L., Ozorowski, G., van der Woude, P., de la Peña, A.T., van Breemen, M.J., Camacho-Sánchez, J.M., Burger, J.A., Medina-Ramírez, M., González, N., Alcami, J., LaBranche, C., Scarlatti, G., van Gils, M.J., Crispin, M., Montefiori, D.C., Ward, A.B., Koopman, G, Moore, J.P., Shattock, R.J., Bogers, W.M., Wilson, I.A. and Sanders, R.W. (2019). Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence. Nature Communications DOI: 10.1038/s41467-019-10262-5

• Kilpeläinen, A., Saubi, N., Guitart, N., Moyo, N., Wee, E.G., Ravi, K., Hanke, T. and Joseph, J. (2019). Priming With Recombinant BCG Expressing Novel HIV-1 Conserved Mosaic Immunogens and Boosting With Recombinant ChAdOx1 Is Safe, Stable, and Elicits HIV-1-Specific T-Cell Responses in BALB/c Mice. Frontiers in Immunology. Vol 10. DOI: 10.3389/fimmu.2019.00923

• Ruiz-Riol, M. and Brander, C. (2019). Can we just kick-and-kill HIV: possible challenges posed by the epigenetically controlled interplay between HIV and host immunity. Immunotherapy, 11(11). Future Medicine, UK. DOI: 10.2217/imt-2019-0092

• Brinkkemper, M. and Sliepen, K. Nanoparticle Vaccines for Inducing HIV-1 Neutralizing Antibodies. (2019). Vaccines, 7(3). MDPI, Switzerland. DOI: 10.3390/vaccines7030076

• Kilpeläinen, A., Saubi, N., Guitart, N., Olvera, A. Hanke, T., Brander, C. and Joseph, J. (2019). Recombinant BCG Expressing HTI Prime and Recombinant ChAdOx1 Boost Is Safe and Elicits HIV-1-Specific T-Cell Responses in BALB/c Mice. Vaccines 7(78). MDPI, Switzerland. DOI: 10.3390/vaccines7030078

• Combadière, B., Beaujean, M., Chaudesaigues, C. and Vieillard, V. (2019). Peptide-Based Vaccination for Antibody Responses Against HIV. Vaccines, 7(3). MDPI, Switzerland. DOI: 10.3390/vaccines7030105

• Eggink, D., Bontjer, I., de Taeye, S.W., Langedijk, J.P.M., Berkhout, B. and Sanders, R.W. (2019). HIV-1 anchor inhibitors and membrane fusion inhibitors target distinct but overlapping steps in virus entry. Journal of Biological Chemistry. DOI: 10.1074/jbc.RA119.007360

• Beltran-Pavez, C., Ferreira, C.B., Merino-Mansilla, A., Fabra-Garcia, A., Casadella, M., Noguera-Julian, M., Paredes, R., Olvera, A., Haro, I., Brander, C., Garcia, F., Gatell, J.M., Yuste, E., Sanchez-Merino, V. (2018)  Guiding the humoral response against HIV-1 toward a MPER adjacent region by immunization with a VLP-formulated antibody-selected envelope variant. PLoS ONE, 13(12): e0208345. December 19. DOI: 10.1371/journal.pone.0208345

• Viegas, E.O., Kroidl, A., Munseri, P.J., Missanga, M., Nilsson, C., Tembe, N., Bauer, A., Joachim, A., Joseph, S., Mann, P., Geldmacher, C., Fleck, S., Stöhr, W., Scarlatti, G., Aboud, S., Bakari, M., Maboko, L., Hoelscher, M., Wahren, B., Robb, M.L., Weber, J., McCormack, S., Biberfeld, G., Jani I.V., Sandström E, Lyamuya E, and TaMoVac study group. (2018). Optimizing the immunogenicity of HIV prime-boost DNA-MVA-rgp140/GLA vaccines in a phase II randomized factorial trial design. PLOS ONE, 13(11).  DOI: 10.1371/journal.pone.0206838

• Crispin, M., Ward, A.B. and Wilson, I.A. (2018). Structure and Immune Recognition of the HIV Glycan Shield. Annual Review of Biophysics, 47(1). DOI: 10.1146/annurev-biophys-060414-034156

• Lopez, E, Shattock, R.J., Kent, S.J. and Chung A.W. (2018). The Multifaceted Nature of Immunoglobulin A and Its Complex Role in HIV. AIDS Research and Human Retroviruses, 34(9). DOI: 10.1089/aid.2018.0099

• Moyo, N., Vogel, A.B., Buus, S., Erbar, S., Wee, E.G., Sahin, U. and Hanke, T. (2018). Efficient Induction of T Cells against Conserved HIV-1 Regions by Mosaic Vaccines Delivered as Self-Amplifying mRNA. Molecular Therapy Methods & Clinical Development DOI: 10.1016/j.omtm.2018.10.010

• Lucar, O., Su, B., Potard, V., Samri, A., Autran, B., Moog, C., Debré, P. and Vieillard, V. (2017). Neutralizing Antibodies Against a Specific Human Immunodeficiency Virus gp41 Epitope are Associated With Long-term Non-progressor Status. EBioMedicine, 22. DOI: 10.1016/j.ebiom.2017.07.007

• Borthwick, N., Lin, Z., Akahoshi, T., Llano, A., Silva-Arrieta, S., Ahmed, T., Dorrell, L., Brander, C., Murakoshi, H., Takiguchi, M. and Hanke, T. (2017). Novel, in-natural-infection subdominant HIV-1 CD8+ T-cell epitopes revealed in human recipients of conserved-region T-cell vaccines. PLoS ONE, 12(4). DOI: 10.1371/journal.pone.0176418

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